The suppressive effect of meperidine on PHA-stimulated transformation of human lymphocytes.
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SAITO, K. and KUMAGAI, K. The Suppressive Effect of Meperidine on PHA- Stimulated Transformation of Human Lymphocytes. Tohoku J. exp. Med., 1981, 134 (3), 337-338-The effect of meperidine on the response of human peripheral lymphocyte in culture to the stimulation by the mitogen, phytohemagglutinin, was studied by measuring the incorporation of 3H-thymidine into DNA. The addition of meperidine at a high concentration (40-200μg/ml) resulted in significant decrease in response to mitogen, the inhibition being dose-dependent. Meperidine may influence immune responses by altering DNA synthesis in the lymphocytes.
- 東北ジャーナル刊行会の論文
東北ジャーナル刊行会 | 論文
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