Comparative Studies on the Adrenal Medullary and Cortical Response to Histamine

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In dogs anesthetized with sodium pentobarbital the adrenal venous blood was collected and subjected to the analyses for adrenal medullary hormones and 17-hydroxycorticosteroids (17-OHCS). A marked increase in adrenal medullary secretion was produced by an intravenous administration of histamine in doses of 0.1 and 0.2mg/kg. A significant increase in adrenal medullary secretion was also observed in dogs adminstered intravenously with 0.01-0.02mg/kg of histamine but not in dogs injected with 0.005mg/kg of histamine. The adrenal 17-OHCS secretion was increased significantly by an intravenous administration of 0.002-0.005mg/kg of histamine. It is concluded that the central nervous system center which controls the adrenal medullary secretion is less sensitive to histamine than the hypothalamopituitary-adrenocortical axis.
東北ジャーナル刊行会の論文