Persistent inhibitory effect of colchicine subperineurially injected to tibial nerve in chicken.
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概要
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Colchicine was subperineurially injected to the tibial nerve in chickens, and it caused a persistent partial paralysis of the leg on the injected side for 60 to 90 days. The injected chickens gradually recovered. Acetylcholinesterase accumulation in the nerve after 24 hr ligation was low until day 36, but high at day 128 of post-treatment. Weight of the gastrocnemial muscle on the injected side decreased to about a half of that of the other side at day 32, then recovered considerably at day 128. The chicken seemed to be a suitable experimental animal to study the mechanism of colchicine effect on the peripheral nerve.
- 公益社団法人 日本獣医学会の論文
公益社団法人 日本獣医学会 | 論文
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