Effect of active vitamin D3 analogs on the osteoporosis of rats caused by ovariectomy.
スポンサーリンク
概要
- 論文の詳細を見る
The effects of 1, 24(R)-dihydroxyvitamin D<SUB>3</SUB>(1, 24(R)(OH)<SUB>2</SUB>D<SUB>3</SUB>), 1, 25-dihydroxyvitamin D<SUB>3</SUB>(1, 25(OH)<SUB>2</SUB>D<SUB>3</SUB>) and 1α-hydroxyvitamin D<SUB>3</SUB>(1α(OH)D<SUB>3</SUB>) on the development of osteoporosis in ovariectomized rats were investigated biochemically and histomorphologically. Vitamin D<SUB>3</SUB> analogs dissoloved in corn oil were given orally to the rats for 6 months after the ovariectomy. The sham-operated control animals received the vehicle alone. Ovariectomy was followed by the development of osteoporosis after 6 months of observation. This was characterized by a reduction in ash content of the tibia and histjologically by a disappearance of the trabecular bone in tibial metaphysis. Biochemical studies showed significant decreases in serum calcium and 1, 25(OH)<SUB>2</SUB>D concentrations, and significant increases in serum immunoreactive parathyroid hormone (iPTH) level in ovariectomized rats. These findings suggest that ovariectomy partially impairs intestinal absorption of calcium, increases bone resorption, and results in a negative calcium balance, which may contribute to the development of osteoporosis in rats. The administration of 1, 24(R)(OH)<SUB>2</SUB>D<SUB>3</SUB>, 1, 25(OH)<SUB>2</SUB>D<SUB>3</SUB> and 1α(OH)D<SUB>3</SUB> increased dose-dependently serum and urinary calcium, but decreased serum iPTH levels to the control level and prevented the development of osteoporosis histologically. These results support the view that active vitamin D<SUB>3</SUB> analogs may be valable tools for the treatment of osteoporosis.
- 公益社団法人 日本獣医学会の論文
公益社団法人 日本獣医学会 | 論文
- Comparison of serum ferritin and oxidative stress biomarkers between Japanese workers with and without metabolic syndrome
- Somatic Cells Count in Cow's Bulk Tank Milk
- Intestinal Smooth Muscle Cells Locally Enhance Stem Cell Factor (SCF) Production against Gastrointestinal Nematode Infections
- Isolation and Molecular Characterization of Methicillin-Resistant Staphylococci from Horses, Personnel and Environmental Sites at an Equine Hospital in Turkey
- Establishment of Hamster Cell Lines with EGFP-Tagged Human XRCC4 and Protection from Low-Dose X-Ray Radiation