Longitudinal Outcome Following Treatment of Hypertension among Patients with Ischemic Vascular Dementia
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概要
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This longitudinal study was designed to measure local cerebral perfusion and volumes of leuko-araiosis among four groups of patients with multiple cerebral infarctions in order to: 1) compare results among those with and those without cognitive impairments and 2) compare results among IVD patients that stabilized and those whose cognitive test performance continued to deteriorate over a follow-up interval of two years. An important part of the study was designed to analyze the effects of control of hypertension among a group of 49 patients with IVD who have been followed prospectively for a mean interval of two years. Results indicate that cognitive impairments among IVD patients are regularly associated with leuko-araiosis. Leuko-araiosis is associated with both ischemia and hypoperfusion of white matter, the latter reflecting disconnections between cortico-thalamic projection systems. Significant improvements in cognitive test performance and neurologic status occurred in IVD patients when systolic blood pressure is controlled within the 135 to 150mmHg range. Progressive cerebral hypoperfusion contributes to cognitive declines in stroke patients with IVD so that early interventions should be instituted for controlling risk factors for stroke, especially hypertension, in order to prevent or improve cognitive deterioration. (Hypertens Res 1994; 17 Suppl. I: S89-S96)
- 日本高血圧学会の論文
日本高血圧学会 | 論文
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