Incorporation and excretion processes of hematoporphyrin derivative into malignant tumor cells in vitro.
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By using a highly sensitive streak-camera technique, we investigate incorporation and excretion processes of HpD into and from malignant tumor m-KSA cells <I>in vitro</I>. The picosecond time-dependent behavior of the fluorescence from HpD in the cells is measured as a function of the incubation and excretion times. The results show that the aggregate component of HpD which has a fast fluorescence lifetime of 100 ps and a red-shifted band of -660 nm in comparison with a monomer band selectively accumulates more andmore in the cells with the increase of the incubation time. Furthermore, it is shown that the aggregate excretes from the cells in the very different manner from the monomer.
- 社団法人 レーザー学会の論文
社団法人 レーザー学会 | 論文
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