In vitro Antifungal Activity of NND-318, a New Imidazole Antimycotic, against Clinical Isolates from Patients with Cutaneous Mycosis.
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In vitro antifungal activity of NND-318, a new imidazole antimycotic, against clinical isolates obtained from patients with cutaneous mycosis was examined in comparison with that of bifonazole (BFZ). The clinical isolates tested were 112 isolates of dermatophytes including Trichophyton mentagrophytes (62 isolates), Trichophyton rubrum (47 isolates), Microsporum canis (2 isolates), Epidermophyton floccosum (1 isolate), and 40 isolates of Candida albicans.MIC values of NND-318 for 112 isolates of dermatophytes distributed in a range of ≤0.0012-0.04μg/ml indicating that NND-318 had more potent in vitro activity than BFZ. MIC values of NND-318 for the isolates of C. albicans distributed in a wide range of 0.63-20μg/ml which were similar to those of BFZ (1.25-20μg/ml).These results showed that in vitro antifungal activity of NND-318 against clinical isolates of dermatophytes and C. albicans was greater than or similar to that of BFZ.
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