In vitro Antifungal Activity of NND-318, a New Antimycotic.
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概要
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The in vitro antifungal activity of NND-318, a new topical imidazole, was studied in comparison with other imidazole antimycotics.NND-318 exhibited potent activity against a wide variety of pathogenic fungi including yeasts, dermatophytes, dematiaceous fungi, dimorphic fungi, Aspergillus spp. and Penicillium spp. Especially, it was 1-64 times more potent against filamentous fungi including dermatophytes and dimorphic fungi than was clotrimazole. The in vitro activity of NND-318, like that of clotrimazole and bifonazole, became less potent with increase in inoculum size and the addition of serum. The activity of NND-318 was not much affected by change in pH, and became more potent with the addition of urea.
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