The Postantifungal Effect: Synergistic Interactions of Cispentacin and Pradimicin (BMY-28864) with Flucytosine against Candida albicans.
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A turbidometric method was used to evaluate Candida albicans yeast cell growth and to quantitate the in vitro postantifungal effect (PAFE) after exposure to various concentrations of cispentacin and pradimicin (BMY-28864), alone and in combination with flucytosine, for 2hr at 30°C and 37°C. Initial MIC and FIC (fractional inhibitory concentration) assays were made to determine approximate drug concentrations to use in the PAFE studies. The PAFE was calculated by the difference in time (hr) required for growth of the control and test cultures to reach the 0.5 absorbance level following removal of the drug by dilution. A synergistic PAFE was evidenced with both cispentacin and pradimicin (BMY-28864) when combined with flucytosine. Optimal PAFEs ranging from 5.7 to 18.5hr were induced by concentrations of cispentacin (0.078 to 0.313μ/ml) and flucytosine (0.049-0.098μg/ml) and from 3.3 to 11.7hr with pradimicin (BMY-28864) (0.078 to 0.313μg/ml) and flucytosine (0.049-0.098μg/ml). The PAFEs persisted for 1.9 to 4.8hr (cispentacin+flucytosine) and for 0.3 to 2.9hr (pradimicin-BMY-28864+flucytosine) longer than those achieved with either agent alone.
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