Activities of Cell Well Polysaccharides from Bakers' Yeast (Saccharomyces cerevisiae) as Biological Response Modifier.
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概要
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Mannan and N-acetylchitohexaose from the cell well of bakers' yeast manifested antitumor activity against several mouse transplantable tumors and protective effects against microbial infections in mice. In order to clarify the underlying mechanism of immunoenhancing effect, we examined the differentiation of thymocyte, splenocyte and lymphocyte in mice administered with WNM or N-acetylchitohexaose by immunofluorescence assays. The ratio of L3T4/Lyt-2 double negative cells was decreased and L3T4 or Lyt-2 single positive cells was increased in thymus and the ratio of double negative cells was increased in lymphnode and spleen in the same mannan-treated mice. The ratio of L3T4+ and Lyt-2+ cells was increased in N-acetylchitohexaose-administered Meth A tumor-bearing mice. On the other hand, two conjugates of mitomycin C and the mannan or N-acetylchitohexaose exhibited a higher growth-inhibition ratio against several mouse syngeneic tumors. These conjugates were also found to kill the same tumor cells in vitro. Because a dextran-mitomycin C conjugate did not manifest any antitumor effect against tumors, it was postulated that interaction of the mannan and N-acetylchitohexaose moiety in the mannan-mitomycin C and N-acetylchitohexaose-mitomycin C conjugates with the mannose/N-acetylchitohexaose receptor locating the cell surface of immunocytes, and/or these tumor cells participated in the common initiating action steps in antitumor effects. The results of binding assay of 14C-labeled mannan-mitomycin C conjugate to tumor cells substantiate this concept.
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