Invasiveness of infecting fungi and tissue response in experimental tinea pedis in guinea pigs.
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概要
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For evaluation of fungal and host factors in pathogenesis of tinea pedis, Trichophyton mentagrophytes zoophilic and anthropophilic strains were compared for invasiveness and induced of tissue response and cell-mediated immunity in experimental tinea pedis in guinea pigs. In vitro comparison of keratinolytic and albuminolytic activities was also made.T. mentagrophytes zoophilic strain SM-110 quickly penetrated the horny layer of an inoculated foot within 24 hours after inoculation, invading the whole horny layer just above the granular layer, provoking a strong inflammatory response and clinical manifestations. Anthropophilic strain NTM-105, in contrast, invaded the upper two-thirds of the horny layer slowly and induced no inflammatory response. Zoophilic strains, SM-110, VUT-85001, VUT-85002 and VUT-85003 showed deep perforations in a hair perforation test and demonstrated clear bovine serum albuminolytic activities, while anthropophilic strains NTM-105 and SM-8500 male only infrequent shallow perforations and showed weak albuminolytic activities. These results indicate that the invasiveness of infecting fungi depends on the protelytic activities of the fungi and relates to the strength of tissue response in tinea pedis.Zoophilic strain SM-110 infections showed clearer response to dermatophyte antigen in intradermal skin test and a lymphocyte stimulation test than did anthropophilic strain NTM-105 infections.In the experimental tinea pedis described herein, it was possible to analyze the strength of tissue reactions, cell-mediated immunity and invasiveness of the infecting fungi.
- 日本医真菌学会の論文
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