Application of liposome-encapsulated amphotericin B for experimental Candida infection in mice.
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概要
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The efficacy of liposome-encapsulated amphotericin B in the treatment of Candida albicans infection in mice was investigated. Amphotericin B was entrapped in small unilamellar vesicles consisting of egg phosphatidylcholine, cholesterol and tocopherol succinate in a molar ratio of 5:2:1. Liposomes exhibited a good stability in serum with a small leakage of carboxy fluorescein. Amphotericin B encapsulated in liposomes resulted in protection of erythrocytes from lysis in isotonic saline. Based on organ distribution of [14C] labeled liposomes, the radioactivity was detected mainly in the liver, spleen, kidney and lung. The highest survival rate was observed at the dosage of liposomal-encapsulated amphotericin B which is lethal to these mice if administered as free amphotericin B.These findings suggest that liposomal encapsulation would be advantageous for delivering amphotericin B in candidiasis.
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