Relationship between urinary and serum D-arabinitol/creatinine ratios in control subjects and patients with invasive candidiasis.

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D-Arabinitol/creatinine ratios were determined in urine and serum specimens simultaneously obtained from control subjects and patients with invasive candidiasis. The mean (±SD) of urinary D-arabinitol/creatinine ratios of male (ages 0-15, 16-65, 66 years old) and female (ages 0-15, 16-65, 66 years old) were 0.4 (±0.4), 0.5 (±0.5), 0.9 (±0.8) and 0.5 (±0.3), 0.6 (±0.9), 0.6 (±0.4) μmol/mg, respectively. The higher incidence of high urinary values was recognized in the older control subjects. These results were similar to the data obtained from serum D-arabinitol values in control subjects. In the patients with invasive candidiasis there was a disagreement between the urinary D-arabinitol/creatinine ratios and the serum ratios. When serum D-arabinitol was increasing, the serum D-arabinitol/creatinine ratio was higher than the urinary D-arabinitol/creatinine ratio. After the effective treatment, the urinary ratio was higher than the serum ratio. Although the determination of serum D-arabinitol is more helpful than the urinary D-arabinitol/creatinine ratio for early diagnostic purposes, the comparison between the urinary ratio and the serum ratio also may be useful to know whether the production of D-arabinitol by Candida is increasing or decreasing in the body.
日本医真菌学会の論文