Tissue responses and fungus configurations. Opportunistic fungal infections in patients with acute leukemia.
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概要
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Opportunistic fungal infections occurring frequently in patients with acute leukemia are candidiasis, aspergillosis and cryptococcosis in that order.<BR>When we try to clarify the relationship between acute leukemia and the fungal infections, it is useful to know about fungal infections to renal transplant recipients. Even though the fungal diseases occurring frequently in renal transplant recipients are the same as those in patients with acute leukemia, the frequency of each fungal disease is definitely different namely, in the renal transplant recipients, cryptococcosis is the fungal disease observed most frequently, followed by candidiasis and aspergillosis in that order.<BR>An explanation for the difference is thought to be as follows : <BR>1. The defense mechanisms of host against Candida albicans, Aspergillus fumigatus or Cryptococcus neoformans are different from each other.<BR>2. The defense mechanisms in patients with acute leukemia are different from those in renal transplant recipients.<BR>3. Ca. albicans is one of the members of normal human flora and A. fumigatus is frequently isolated from air. We contact them frequently in daily life. However, it is usually difficult to isolate Cr, neoformans from living circumstances or nature.<BR>Due to the difference in combinations of these factors, the frequency of each fungal disease occurring in patients with acute leukemia is different from that in renal transplant recipients.
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