Growth regulation of Kagura-2 cells established from aflatoxin B<SUB>1</SUB>-induced rat hepatocellular carcinoma by glucocorticoid
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To gain an insight into the growth regulation of Kagura-2 cells derived from aflatoxin B<SUB>1</SUB> (AFB<SUB>1</SUB>)-induced rat hepatocellular carcinoma by glucocorticoid (GC), we analyzed the growth factors in the conditioned medium of Kagura-2 cells (K2-CM). Kagura-2 cells secrete at least three kinds of growth factors including a transforming growth factor-β (TGF-β)-like factor, a fibroblast growth factor (FGF)-like factor and an unknown inhibitory factor. Moreover, the inhibitory activity in K2-CM prepared in the presence of dexamethasone (DEX) tends to be lower than in that obtained in the absence of DEX. From these data, it is highly possible that GC-dependent growth of Kagura-2 cells is regulated through these stimulatory and inhibitory factors in an autocrine and/or a paracrine mechanism.
- 日本マイコトキシン学会の論文
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