Inhibition of mitochondrial respiration by emestrin, a new mycotoxin from Emericella species

概要

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Emestrin, a new epidithiodioxopiperazine mycotoxin isolated from Emericella species, was examined for the effects on mitochondrial structure and function using isolated rat liver mito-chondria to gain an insight into the molecular mechanism of its in vivo toxicity. Emestrin was found to inhibit the ATP synthesis in mitochondria, exerting an uncoupling effect on oxidative phosphorylation in mitochondria. Emestrin was further observed to elicit a marked swelling of mitochondria in the isotonic KCl solution at the significantly lower concentrations than those for its uncoupling effect on oxidative phosphorylation. These results show a good agreement with the results in vivo toxicity test using rats and mouse, in which mitochondria were significantly impaired showing a drastic structural deformation (swelling) in liver and heart, which strongly suggests a direct toxic action of emestrin on mitochondria in vivo.
日本マイコトキシン学会の論文