Antiviral activity of T-2 toxin and related compounds against herpes simplex virus type 2 in vitro
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概要
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The effects of the trichothecene mycotoxins, T-2 toxin, diacetoxyscirpenol and neosolaniol, on plaque formation by herpes simplex virus type 2 (HSV-2) in HEp-2 cells were determined. The 50% inhibitory concentrations for plaque production by HSV-2 were 2.3 ng/ml for T-2 toxin, 2.6 ng/ml for diacetoxyscirpenol, and 57.0 ng/ml for neosolaniol. Neither virus replication nor synthesis of virus-specific polypeptides was observed in the cells treated with the trichothecenes at concentrations completely inhibiting plaque formation. Plaque formation by HSV-2 was not inhibited by treatment of the cells with the trichothecenes for 1 hr postin-fection or for 15 hr before infection. These results indicate that the trichothecenes can affect HSV-2 in the stage of viral protein synthesis after infection, but not in the stage of virus adsorption to the host cells.
- 日本マイコトキシン学会の論文
日本マイコトキシン学会 | 論文
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