Effect of the chronic unilateral lesion in the nucleus tractus solitarii on cerebral hemodynamics and chemical vasomotor responses.
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The nucleus tractus solitarii (NTS) has been demonstrated to send efferent fibers to the locus ceruleus and the hypothalamus which are closely related to autonomic nervous functions. However, the participation of the NTS in cerebral hemodynamics and cerebral vasomotor responses has not been clarified. The present study, therefore, was aimed at elucidating the role of the NTS in these themes using chronic monkey model.<BR>Studies were undertaken in 17 monkeys (macaca fuscata) weighing 6.1 ± 1.7 kg. An electrode was stereotaxically inserted into the right intermediate portion of the NTS and the lesion was made by electrical coagulation in 12 monkeys, and sham operation was done in 5 monkeys. Seven days later, the animals were anesthetized with α-chloralose and urethane. PaCO<SUB>2</SUB> and body temperature were maintained within a physiological range. Bilateral internal carotid blood flows (ICBF) were continuously measured by electromagnetic flowmeters with blood pressure and pulse rate. Cerebral vasomotor responses were quantitatively analyzed by means of chemical vasomotor index (CVI=ΔICBF/ΔPaCO<SUB>2</SUB>, ml/min/mmHg). Cerebral venous blood samples were drawn from the sagittal sinus for measurements of cerebral oxygen consumption (CMRO<SUB>2</SUB>).<BR>I) Blood pressure and pulse rate : No significant difference were observed between NTS lesion and sham groups in the steady state.<BR>II) ICBF and CMRO<SUB>2</SUB> : In the lesion group, while ICBF showed a tendency to differ between lesion and non-lesion sides, no significant differences were obtained as compared with the sham group. CRMO<SUB>2</SUB> had no significant difference between lesion and sham groups.<BR>III) CBF chemical regulation : The cerebral vasomotor response to induced hypercapnia was significantly higher in the lesion side than in the non-lesion side (p<0.05). On the other hand, the response to induced hypocapnia in the non-lesion side was significantly lower as compared with that in the lesion side (p<0.05) and had the tendency to be lower as compared with that in the sham group.<BR>The results suggest that the unilateral lesion of the NTS modulates cerebral chemical vasomotor responses through the neuronal networks without a significant alteration of cerebral metabolism.
- 一般社団法人 日本脳卒中学会の論文
一般社団法人 日本脳卒中学会 | 論文
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