Effect of calcium antagonist NC-1100 on local cerebral blood flow and tissue metabolism during acute cerebral ishcemia in spontaneously hypertensive rats.
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The effects of a novel calcium antagonist, NC-1100, on local cerebral blood flows (CBF) and brain tissue metabolites such as lactate, pyruvate and ATP were examined in spontaneously hypertensive rats (SHR) of which both carotid arteries were ligated (BCL). CBF in the cerebral and cerebellar cortices were measured by the hydrogen clearance method.<BR>At rest, NC-1100 (0.2 and 1.0 mg/kg, IV) increased blood flows to the cerebrum by 25 and 22%, and to the cerebellum by 13 and 18%, respectively, while it transiently reduced mean atrial blood pressure (MABP) by 28 and 45%.<BR>During BCL, CBF reduction in both cortices did not significantly differ between saline and NC-1100 treated SHR.<BR>One hour after BCL, the increase in brain lactate was 26.6 ± 1.7 mmol/kg in the saline group, being larger than 23.5 ± 2.2 and 22.8 ± 2.3 in the NC-1100 0.2 and 1.0 mg/kg treated groups, respectively. In contrast, ATP levels remained higher in the NC-1100 treated groups (0.80 ± 0.19, 0.97 ± 0.24 mmol/kg in 0.2 and 1.0 mg/kg, respectively) than in the saline given group (0.61 ± 0.04 mmol/kg).<BR>These results indicate that NC-1100 protects brain metabolism against acute ishcemia, suggesting a beneficial effect of this agent for treatment of acute cerebral infarction.
- 一般社団法人 日本脳卒中学会の論文
一般社団法人 日本脳卒中学会 | 論文
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