Usefulness of Colloid Osmotic Pressure (COP) Monitoring in Evaluating the Severity of Critically Ill Patients.

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The aim of this study was to determine the usefulness of colloid osmotic pressure (COP) monitoring in evaluating the severity of critically ill patients. The subjects consisted of 118 randomly selected patients. One month after their admission to the ICU, 98 patients were alive and 20 had died. The COP values were directly determined using a colloid osmometer, model 4420, at 8.00AM every day. Correlations between COP levels and APACHE-II scores upon admission, patient data, and patient prognosis were evaluated. Differences between outcome (survived, died) were analyzed using the Mann- Whitney U-test (p<0.05). Correlations between serum concentrations of protein and albumin and COP levels were also estimated. A linear analysis was performed, and a significant correlation was identified between COP levels and APACHE-II scores upon admission. The APACHE-II scores of the subjects that survived were significantly lower than those that died, and the COP levels in those that survived were significantly higher than those that died. We did not observe any correlations between either serum protein levels or albumin concentrations and COP levels. These results indicate that COP measurements taken using a colloid osmometer are useful for evaluating the severity of critically ill patient. COP measurements could be used as a rapid and accurate method of monitoring patients in the ICU.
一般社団法人日本救急医学会の論文