Increased Organ Blood Flow Induced by Acetazolamide. Change in Vasodilator Factors.:Change in Vasodilator Factors
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概要
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The purpose of this study was to evaluate the increased organ blood flow induced by acetazolamide (AZ) by comparing changes in blood flow (BF) in organs and levels of vasodilation factors after administration of AZ and CO2 inhalation. Method: The BF in the livers, kidneys, stomach walls, and abdominal muscles of rabbits were measured with a laser flowmeter while AZ was administered. In addition, cardiac output, and levels of PGI2, endothelin (ET-1), and NO were measured. These measurements were also made while CO2 was inhaled. Result: BF in the rabbit liver and kidney were increased by AZ administration. However, BF in the stomach wall and the abdominal muscle, as well as levels of PGI2, ET-1, and NOx remained unchanged after AZ administration. On the other hand, BF in all 4 organs, and the levels of PGI2 and ET-1, increased while CO2 gas was inhaled. Conclusion: The results suggest that the increase in BF in response to AZ was specific to the liver and kidney both of which contain large quantities of carbonic anhydrase, therefore, the mechanism of AZ-induced vasodilation was thought either to result from retention of CO2, or from a mechanism different from the inhibition of CO2.
- 一般社団法人 日本救急医学会の論文
一般社団法人 日本救急医学会 | 論文
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