CLINICAL STUDY ON MULTIPLE ORGAN FAILURE IN ABDOMINAL SEPSIS:ESPECIALLY ON OXYGEN TRANSPORT AND CELL DAMAGE
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概要
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In order to investigate the pathophysiology of multiple organ failure (MOF) in sepsis, 112 patients with abdominal sepsis were studied. Twenty-nine of these patients manifested MOF. Severe respiratory failure was observed in these MOF patients, and the activities of serum enzymes such as GOT and LDH were significantly elevated, suggesting that systemic cell damage occurred. While oxygen delivery was maintained with intensive cardiorespiratory care in spite of the severe respiratory failure, both oxygen consumption and mixed venous pH decreased. Therefore, failure of oxygen usage despite its availability occurred in the patients with MOF. This was probably due to arteriovenous shunts or to the direct influence of endotoxin on cell metabolism, and might be the cause of the cell damage. These results suggest that the improvement of cell metabolism is necessary in the treatment of patients with MOF.
- 日本臨床外科学会の論文
日本臨床外科学会 | 論文
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