Expression and Regulation of the Gene for Arginase I in Mouse Salivary Glands: Requirement of CCAAT/Enhancer-Binding Protein .ALPHA. for the Expression in the Parotid Gland.
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概要
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Arginase in salivary glands is potentially involved in the synthesis of proline, glutamate, and polyamines that play specific physiological roles in the glands, and also in depletion of arginine in the oral cavity to protect teeth from microorganisms. We detected protein and mRNA for the type I isoform of arginase in mouse salivary glands. Enzymes of the arginine-biosynthetic pathway were also detected. Immunohistochemical analysis revealed that arginase I was enriched in the striated duct, and was also present in the acinus, demilune and granulated duct. Mice with targeted disruption of the gene for C/EBPα, which is a transcription factor essential for expression of the arginase I gene in the liver, showed dramatically reduced immunoreactivity for arginase I in the parotid gland but not in the submandibular and sublingual glands. Therefore, CIEBPα is specifically required for expression of the arginase I gene in the parotid gland.
- 社団法人 日本生化学会の論文
著者
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Shimizu-yabe Atsuko
Department Of Biochemistry And Genetics Chiba University Graduate School Of Medicine
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HIWASA TAKAKI
Department of Biochemistry (I), Chiba University School of Medicine
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Tanzawa Hideki
Department Of Clinical Molecular Biology Chiba University Graduate School Of Medicine
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Mori Masataka
Department Of Electrical Engineering Nagaoka University Of Technology
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Takiguchi Masaki
Department Of Biochemistry And Genetics (e1) Graduate School Of Medicine Chiba University
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Kubosawa Hitoshi
Department Of Clinical Pathology Chiba Municipal Hospital
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Akiba Tsugino
Department Of Biochemistry And Genetics Chiba University Graduate School Of Medicine
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Iwase Katsuro
Department Of Biochemistry And Genetics Chiba University Graduate School Of Medicine
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Yokoe Hidetaka
Department Of Clinical Molecular Biology Chiba University Graduate School Of Medicine
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Kuroiwa Namiko
Department Of Biochemistry And Genetics Chiba University Graduate School Of Medicine
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Kageyama Ryoichiro
Institute For Virus Research Kyoto University
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Dahrington Gretchen
Department Of Pathology Huffington Center On Aging Baylor College Of Medicine
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Shimizu Atsuko
Department of Biochemistry and Genetics, Chiba University Graduate School of Medicine
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