Estimation of Circulating Renin in Normal and Toxemic Pregnancy

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Plasma renin was estimated in forty-five women; 18 non-pregnant, 11 normal pregnant, 13 toxemic pregnant and 3 postpartum. It was found that plasma renin was within normal range in all of the non-pregnant and normal pregnant groups, and two of the post partum group. In one patient of the last group a high value was obtained, though it was by far lower than that in toxemic pregnancy. Eight of the 13 patients in the toxemic group were observed to have increased plasma renin. It is evident from this study that the renin-angiotensin system is concerned in the toxemia of pregnancy. But the question as to whether the elevated renin in toxemia originates from the kidney or from the pathological placenta is not yet solved.
東北ジャーナル刊行会の論文