Prognostic Significance of Simultaneous Infiltration of HLA-DR-Positive Dendritic Cells and Tumor Infiltrating Lymphocytes into Human Esophageal Carcinoma.

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FURIHATA, M., OHTSUKI, Y., SONOBE, H., ARAKI, K., OGATA, T., TOKI, T., OGOSHI, S. and TAMIYA, T. Prognostic Significance of Simultaneous Infiltration of HLA-DR-Positive Dendritic Cells and Tumor Infiltrating Lymphocytes into Human Esophageal Carcinoma. Tohoku J. Exp. Med., 1993, 169 (3), 187-195- The distribution of HLA-DR-positive dendritic cells (DR+DCs) and tumor infiltrating lymphocytes (TILs) was investigated in 67 patients with squamous cell carcinoma of the esophagus. DR+DCs were chiefly present among the cancer cell nests, and few were seen in the stroma. As clusters, UCHL-1-positive T-cells (UCHL1-Ts) were detected in the tissue around the cancer cell nests and as individual cells within tumor nests. Some UCHL1-Ts in the tumor nests showed direct contact with DR+DCs. In addition, a few OPD4-positive helper/inducer T cells were found among cancer cells, and were densely present in the stroma. A correlation was demonstrated between the number of DR+DCs and UCHL1-Ts in each patient (R=0.4547, p<0.01). In addition, dense tumor infiltration by both DR+DCs and UCHL1-Ts within the cancer cell nests was related to a better prognosis (p<0.01).- HLA-DR; dendritic cell; lymphocyte; esophageal cancer
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