Biocompatible Evaluation of Ion-beam Irradiated PTFE Felt

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Polytetrafluoroethylene (PTFE) felt is one of the medical materials used for brain surgery and cardiovascular surgery, such as reinforcement of the suture part, prosthesis of the defect part after the excision. However there are many problems due to its poor adhesion to around tissue. This study concerns fabrication of new cell adhesive materials by ion irradiation into PTFE felt. PTFE felt was irradiated with He+- and Kr+ -beams at fluences of 1×1014, 5×1014, and 1×1015 ions/cm2 at an energy of 150 keV. Surface characterization was performed by SEM, X-ray photoelectron Spectroscopy (XPS), and contact angle measurement. L929 mouse fibroblast cells were cultured on ion-irradiated specimen as cell attachment study. XPS measurement shows CF2 bonds were destroyed and C-C and C=C bonds were generated. From the results of cell cultivation, cell attachment to the ion-irradiated felt was dramatically improved as compared with non-irradiated PTFE felt. In our experiment, Kr+ beam irradiated PTFE felt at a fluence of 5×1014 ions/cm2 showed the most excellent cell attachment. Animal study demonstrated that tissue invasion was dramatically enhanced by ion-beam irradiation. These results indicated the possibility of ion-beam irradiated PTFE felt for clinical application.
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