Bioinspired phospholipid polymer for improvement of biofouling on titanium alloy substrate

概要

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Inspired by mussel adhesion mechanism, a new bioinspired polymer containing phospholipid polar groups for ultra-low biofouling was designed. The polymer (named as PMDP) was composed of both 2-methacryloyloxyethyl phosphorylcholine (MPC) unit and 3,4-dihydroxyphenyl group for surface anchoring. The PMDP coating with 20 nm in thickness could be formed on titanium (Ti) alloy substrate simply by 10s dip coating without drying process. Even when the Ti alloy substrate with PMDP coating was immersed in the aqueous medium for a week, no change in the thickness was observed, that is, the PMDP adhered very stably. Adsorption of protein occurred on the Ti alloy substrate; however, it could not be observed on the PMDP coated Ti alloy substrate. Thus, the PMDP coating was effective to suppress biofouling. It is concluded that the surface treatment process with PMDP is quite simple, quick and reliable, which has great potential for improvement of biofouling on the Ti alloy substrate as implant devices.
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