チーズの経口摂取によるラットの肝臓における脂質代謝改善効果

概要

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Increasing reports suggest that cheese intake lowers the risk of developing metabolic syndrome (MS). However, the mechanism by which cheese prevents MS is poorly understood. In this study, we investigated the effect of cheese on improvement of lipid metabolism in liver using a fatty liver model induced by high fat plus cholesterol diet. Rats were fed for 28 days as followed; high fat diet (Hfat), high fat plus cholesterol diet (Control), or cheese plus cholesterol diet (Cheese). Then hepatic and fecal lipid were analyzed. The results showed that, in the cheese fed group, liver triglyceride and cholesterol as well as liver weight were significantly lower than those of control group. In addition, the fecal lipid level in cheese fed group was significantly higher than that of control group. These results suggest that the beneficial effects of cheese on metabolic syndrome may be due to lowering the fat deposition in liver and increasing fat excretion from feces.
日本酪農科学会の論文