Experimental studies on the gastroduodenojejunal motility and gastric emptying after duodenectomy with preservation of the total stomach and pylorus.

概要

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It is of interest to know whether or not the removal of the pyloric branch of the vagus nerve (subsequently referred to as vagotomy) is associated with the eary stagnation of gastric contents supervening upon duodenectomy with preservation of the total stomach and pylorus (innervation of pylorus group 5, denervation of pylorus group 5). In the present study preservative duodenectomy was performed on dogs to determine the effects of vagotomy on gastroduodenojejunal motility and gastric emptying. The group of typical strong preprandial contraction waves (subsequently referred to as phase III) did not appear after vagotomy. The appearance of phase III was delyed and its duration was reduced. The duration of pyloric phase III significantly reduced, at 2 and 4 weeks post-surgery, in the dennervation of pylorus group, compared to the innervation of pylorus group, and at 4 weeks, the area of phase III was significantly decresed in the dennervation group.Postvagotomy gastric emptying was poor throughout the course of observation. The results of this study suggest that the vagotomy-induced change in gastroduodenal motility in fasting conditions is one of the factors responsible for the stangnation of gastric contents.
日本平滑筋学会の論文