Determination of In Vitro Activities of Polymyxin B and Rifampin in Combination with Ampicillin/Sulbactam or Cefoperazone/Sulbactam against Multidrug-Resistant Acinetobacter baumannii by the E-test and Checkerboard Methods

スポンサーリンク

概要

• 論文の詳細を見る

• The aim of this study was to investigate the in vitro activities of polymyxin B (PB) and rifampin (RIF) in combination with ampicillin/sulbactam (AS) or cefoperazone/sulbactam (CS) against 20 multidrug-resistant Acinetobacter baumannii (MDR-AB) isolates by the checkerboard and E-test methods. Fractional inhibitory concentration index (FICI) values were defined as synergy, FICI ≤ 0.5; additivity, 0.5 < FICI ≤ 1.0, indifference, 1.0 < FICI < 4.0; and antagonism, FICI ≥ 4. Synergistic interaction was detected only for the RIF + AS and RIF + CS combinations. While the most frequently detected interaction type for PB + AS or PB + CS combinations was indifference, some showed antagonistic interactions. The detection rate of synergy was significantly higher by the checkerboard than by the E-test method, and the detection rate of indifference was significantly higher by the E-test than by the checkerboard method for RIF + AS combination (P ≤ 0.0001). In addition, no statistically significant difference was detected between the checkerboard and E-test methods for the detection rates of interaction types for any of the other combinations (P > 0.05), except for PB + CS combination for the detection of additivity (P = 0.018). Owing to the high percentage of synergistic interactions between RIF and AS, we considered this combination as an effective therapeutic option for MDR-AB infections.

• National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committeeの論文

著者

• Aridogan Buket

  Department Of Microbiology And Clinical Microbiology Suleyman Demirel University Faculty Of Medicine

• Cetin Emel

  Department of Microbiology and Clinical Microbiology, Medical Faculty of Suleyman Demirel University

• Tekeli Alper

  Department of Microbiology and Clinical Microbiology, Medical Faculty of Ankara University

• Ozseven Ayşe

  Department of Medical Microbiology, Faculty of Medicine, Kafkas University

• Us Ebru

  Department of Microbiology and Clinical Microbiology, Medical Faculty of Ankara University

関連論文

• Tissue Parasites in Patients with Chronic Urticaria
• Pansclerotic Morphea Treated with UVA : A Case Report
• Serum Levels of IL-4, IL-10, IL-12, IL-13 and IFN-Gamma in Behcet's Disease
• Determination of In Vitro Activities of Polymyxin B and Rifampin in Combination with Ampicillin/Sulbactam or Cefoperazone/Sulbactam against Multidrug-Resistant Acinetobacter baumannii by the E-test and Checkerboard Methods

スポンサーリンク