Preoperative 18F-Fluorodeoxyglucose Positron Emission Tomography can Predict the Tumor Malignancy of Small Peripheral Lung Cancer
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概要
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Purpose: Recent advances in image diagnostic technology have enhanced the discovery of peripheral small size lung cancers. Here, we examined the utility of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) for the evaluation of grade of tumor malignant potency.Methods: Seventy-nine patients with peripheral small lung cancers (≤2 cm) who underwent surgical resections and preoperative FDG-PET were enrolled. The correlations between the maximum standardized uptake value (SUVmax) and various clinicopathological features related to tumor invasiveness, nodal metastasis, and recurrence were analyzed.Results: The median SUVmax of all tumors was 2.4 (range, 0–16.1). The SUVmax was significantly higher in patients with vascular invasion (5.6 ± 3.5 vs. 2.4 ± 2.4; P <0.0001), lymphatic invasion (4.9 ± 3.7 vs. 2.7 ± 2.6; P = 0.0029), lymph node metastasis (6.1 ± 4.4 vs. 3.0 ± 2.7; P = 0.0022), and recurrences (5.8 ± 3.3 vs. 3.1 ± 3.1; P = 0.0219). Patients with SUVmax ≥2.5 had a significantly higher incidence rate of vascular invasion (56% vs. 7%; P <0.0001), lymphatic invasion (51% vs. 15%; P = 0.0006), lymph node metastasis (26% vs. 3%; P = 0.0033), and recurrence (18% vs. 3%; P = 0.0289). The patients with SUVmax ≥1.5 also had a significantly higher incidence of vascular invasion, lymphatic invasion, lymph node metastasis, and recurrence. It is particularly worth noting that patients with SUVmax <1.5 had no vascular invasion, lymph node metastasis, or recurrence.Conclusion: Preoperative SUVmax of peripheral small lung cancers were significantly associated with tumor malignancy.
- Annals of Thoracic and Cardiovascular Surgery 編集委員会の論文
著者
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Kuwano Hiroyuki
Department Of General Surgical Science (surgery 1) Gunma University Graduate School Of Medicine
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Yamaki Ei
Department Of General Surgical Science (surgery 1) Gunma University Graduate School Of Medicine
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Tanaka Shigebumi
Department Of General Surgical Science Gunma University Graduate School Of Medicine
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Kosaka Takayuki
Department Of General Surgical Science Gunma University Graduate School Of Medicine
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Mogi Akira
Department of General Surgical Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
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Mogi Akira
Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi, Gunma, Japan
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Tanaka Shigebumi
Department of General Surgical Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
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Kosaka Takayuki
Department of General Surgical Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
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Yamaki Ei
Department of General Surgical Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
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