Asymptomatic Patients with Acute Leukemias and Malignant Lymphomas Found in Ningen Dock

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Background The prognosis of hematological malignancies is still unsatisfactory despite recent advances in therapeutic modalities. However, the effectiveness of their early detection has not been evaluated. We report on asymptomatic patients with acute leukemias or malignant lymphomas detected in ningen dock and compare their clinical courses with symptomatically diagnosed patients.Methods Among 222 patients with acute leukemias or malignant lymphomas that we diagnosed between 1998 and 2008, 5 asymptomatic patients were referred by ningen dock centers. Their diseases were acute promyelocytic leukemia, acute lymphoblastic leukemia, follicular lymphoma, diffuse large B cell lymphoma, and small lymphocytic lymphoma, respectively. Their survival time following completion of chemotherapy was analyzed in comparison with symptomatically diagnosed patients.Results All of the 5 patients remained alive during observation periods ranging from 25 to 131 months (median 58) with no particular events. However, event-free survival rates at 5 and 10 years for the 217 symptomatic patients were 29.9% and 14.8%, respectively.Conclusion Although more precise analyses are required, we postulate that the widely practiced ningen dock and population-based screening could improve the prognosis for hematological tumors by detecting them at an earlier stage. Therefore, closer relationships between ningen dock centers and institutes where detailed hematological examinations are carried out should be established. (Ningen Dock 2010; 24: 21-24)
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Asymptomatic Patients with Acute Leukemias and Malignant Lymphomas Found in Ningen Dock

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