Effective Control of Relapsing Disseminated Intravascular Coagulation in a Patient with Decompensated Liver Cirrhosis by Recombinant Soluble Thrombomodulin

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概要

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• A 70-year-old Japanese man was hospitalized for expanding purpura and chronic disseminated intravascular coagulation (DIC) caused by decompensated liver cirrhosis. As there are no effective treatments for chronic DIC caused by liver cirrhosis, we decided to administer recombinant human soluble thrombomodulin (rhsTM) after he provided informed consent. The DIC was rapidly improved; however, the purpura and coagulopathy recurred after two months, and repeated rhsTM treatments were required. The rhsTM treatment sufficiently controlled the coagulopathy for two years, without any complications, including bleeding. This is the first report demonstrating that rhsTM can be administered safely and repeatedly to a patient with decompensated liver cirrhosis, and that it appears to be associated with a favorable outcome.

著者

• SAWADA KOJI

  Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine

• Ohtake Takaaki

  Division Of Gastroenterology And Hematology/oncology Department Of Medicine Asahikawa Medical Colleg

• Kohgo Yutaka

  Division Of Gastroenterology And Hematology/oncology Department Of Medicine Asahikawa Medical Colleg

• Fujiya Mikihiro

  Division Of Gastroenterology And Hematology/oncology Department Of Medicine Asahikawa Medical Univer

• Abe Masami

  Division Of Cardiology Department Of Medicine Kameda Medical Center

• Abe Masami

  Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Japan

• Ohtake Takaaki

  Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Japan

• Hasebe Takumu

  Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Japan

• Nakajima Shunsuke

  Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Japan

• Maeda Shigeaki

  Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Japan

• Suzuki Yasuaki

  Department of Gastroenterology, Nayoro City General Hospital, Japan

• Hasebe Chitomi

  Department of Gasroentelorogy, Asahikawa Red Cross Hospital, Japan

• Fujiya Mikihiro

  Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Japan

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