Anticonvulsant Effects of Fuzi Total Alkaloid on Pentylenetetrazole-Induced Seizure in Mice
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概要
- 論文の詳細を見る
We investigated the anticonvulsant effect of acute Fuzi total alkaloid (FTA) in seizure induced by the GABAA-receptor antagonist pentylenetetrazole (PTZ). FTA significantly increased the seizure latency and decreased the mortality in PTZ-treated mice. Administration of PTZ increased c-Fos expression in the hippocampus, medial prefrontal cortex, and piriform cortex; and this PTZ-induced effect was inhibited by FTA in a dose-dependent manner. Furthermore, the effects of FTA on PTZ-induced seizure and c-Fos expression were reversed by the GABAA/benzodiazepine receptor–selective antagonist flumazenil. These findings suggest that the anticonvulsant effects of FTA may be related to modulation of GABAA–benzodiazepine receptor complex.
- 公益社団法人 日本薬理学会の論文
著者
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Zhao Jing
National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, China
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Liu Lei
National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, China
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Li Yuxin
National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, China
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Wang Liang
National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, China
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Tang Fang
National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, China
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Li Bingjin
National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, China
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Zhou Yang
National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, China
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Wang Yinuo
National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, China
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Song Yunong
National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, China
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Cui Ranji
National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, China
関連論文
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- Anticonvulsant Effects of Fuzi Total Alkaloid on Pentylenetetrazole-Induced Seizure in Mice