Corneal Mineralization in Wistar Hannover Rats

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概要

• 論文の詳細を見る

• We have recently started using Wistar Hannover rats in Japan and are now collecting background data. We have been frequently observing corneal mineralization in Wistar Hannover rats of both the RccHanTM:WIST and Crl:WI (Han) strains. In this study, details of corneal mineralization in Wistar Hannover rats were histopathologically and ultrastructurally investigated. According to the results, Wistar Hannover rats had a much higher incidence of corneal mineralization compared with Sprague-Dawley rats. The incidence of corneal mineralization was higher in males than females. According to the histological examination, mineral deposits were positive for calcium by von Kossa's method. Furthermore, in response to mineralization, keratocytes probably become active to play an important role against the mineralized substance.

• 日本毒性病理学会の論文

著者

• Wako Yumi

  Pathology Department, Kashima Laboratory, Nonclinical Research Center, Mitsubishi Chemical Medience Corporation, 14-1 Sunayama, Kamisu, Ibaraki 314-0255, Japan

• Sato Junko

  Pathology Department, Kashima Laboratory, Nonclinical Research Center, Mitsubishi Chemical Medience Corporation, 14-1 Sunayama, Kamisu, Ibaraki 314-0255, Japan

• Doi Takuya

  Pathology Department, Kashima Laboratory, Nonclinical Research Center, Mitsubishi Chemical Medience Corporation, 14-1 Sunayama, Kamisu, Ibaraki 314-0255, Japan

• Tsuchitani Minoru

  Pathology Department, Kashima Laboratory, Nonclinical Research Center, Mitsubishi Chemical Medience Corporation, 14-1 Sunayama, Kamisu, Ibaraki 314-0255, Japan

• HASHIMOTO Satomi

  Pathology Department, Kashima Laboratory, Nonclinical Research Center, Mitsubishi Chemical Medience Corporation, 14-1 Sunayama, Kamisu, Ibaraki 314-0255, Japan

• WADA Sou

  Safety Assessment Department, Kashima Laboratory, Nonclinical Research Center, Mitsubishi Chemical Medience Corporation, 14-1 Sunayama, Kamisu, Ibaraki 314-0255, Japan

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