Infectivity of Cryptosporidium andersoni and Cryptosporidium muris to Normal and Immunosuppressive Cynomolgus Monkeys

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概要

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• Cryptosporidium andersoni and Cryptosporidium muris infections have been found in the mice and/or cattle. The oocysts of C. andersoni and C. muris have been sporadically detected in human feces, but the infectious capacity and features have been unknown, because of the scarcity of reports involving human infections. To assess the infectivity and the clinical and pathological features of C. andersoni and C. muris in primates, an experimental infectious study was conducted using cynomolgus monkeys. The monkeys were orally inoculated with oocysts of two different C. andersoni Kawatabi types and C. muris RN-66 under normal and immunosuppressive conditions. The feces of the monkeys were monitored for about 40 days after the administration of oocysts using the flotation method, but no shedding oocysts were observed under either both normal or immunosuppressive conditions. Gross and histopathological examinations were performed on the immunosuppressive monkeys, but these revealed no evidence of Cryptosporidium infections, even though the monkeys were subjected to immunosuppressive conditions. It is hypothesized that C. andersoni and C. muris pose little danger of infection in primates even under immunosuppressive conditions.

• 公益社団法人 日本獣医学会の論文

著者

• Masuno Koichi

  Drug Safety Evaluation Developmental Research Laboratories Shionogi & Co. Ltd.

• Nakai Yutaka

  Laboratory Of Animal Health And Management Graduate School Of Agricultural Science Tohoku University

• YANAI Tokuma

  Veterinary Medicine, Gifu University

• KUBO Masahito

  Veterinary Medicine, Gifu University

• FUKUDA Yasuhiro

  Laboratory of Sustainable Environmental Biology, Graduate School of Agricultural Science, Tohoku University

• IKARASHI Ryo

  Laboratory of Sustainable Environmental Biology, Graduate School of Agricultural Science, Tohoku University

• KURAISHI Takeshi

  The Institute of Medical Science, The University of Tokyo

• HATTORI Shosaku

  The Institute of Medical Science, The University of Tokyo

• KIMURA Junpei

  Korea Secretary General of Asian Society of Zoo and Wildlife Medicine, College of Veterinary Medicine, Seoul National University

• KAI Chieko

  The Institute of Medical Science, The University of Tokyo

• MASUNO Koichi

  Drug Developmental Research Laboratories, Shionogi & Co., Ltd.

関連論文

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• Recent Topics of Animal Health and Management
• Ammonia-Oxidizing Bacteria Rather than Ammonia-Oxidizing Archaea were Widely Distributed in Animal Manure Composts from Field-Scale Facilities
• Infectivity of Cryptosporidium andersoni and Cryptosporidium muris to Normal and Immunosuppressive Cynomolgus Monkeys

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