Discussion about Several Potential Drawbacks of PEGylated Therapeutic Proteins

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概要

• 論文の詳細を見る

• PEGylation changes the physical and chemical properties of the biomedical molecule, such as its conformation, electrostatic binding, and hydrophobicity, and results in an improvement in the pharmacokinetic behavior of the drug fwhile it also causes some disadvantages of which cannot be neglected. The available data manifests that PEG (Polyethylene glycol) itself shows potential risk, such as immunogenicity of the PEG and PEG-containing vacuoles in cells observed with PEGylated biologicals. Decreased activity and heterogeneity are also the negative aspects of PEGylation. The unfavorable impacts which are brought by the PEGylation are described here with examples of modified therapeutic proteins on the market and used in the clinical trials.

• 公益社団法人 日本薬学会の論文

著者

• Zhang Fan

  Biological Engineering Institute of Zhejiang Chinese Medical University

• Liu Mu-rong

  BIODOOR Biotechnology Co., Ltd of Hangzhou City in Zhejiang Province

• Wan Hai-tong

  Biological Engineering Institute of Zhejiang Chinese Medical University

関連論文

• Discussion about Several Potential Drawbacks of PEGylated Therapeutic Proteins

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