MurA as a Primary Target of Tulipalin B and 6-Tuliposide B

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概要

• 論文の詳細を見る

• (−)-Tulipalin B and (+)-6-tuliposide B were confirmed to inhibit MurA in vitro. However, contrary to fosfomycin, these compounds showed potent inhibitory activities against MurA overexpressing Escherichia coli, especially in the presence of UDP-GlcNAc. These observations suggest that these compounds induced bacterial cell death not through a MurA malfunction, but in such a MurA-mediated indirect manner as the inhibition of other Mur enzymes.

• 公益社団法人 日本農芸化学会の論文

著者

• SHIGETOMI Kengo

  Division of Applied Bioscience, Research Faculty of Agriculture, Hokkaido University

• Shigetomi Kengo

  Division Of Applied Bioscience Graduate School Of Agriculture Hokkaido University

• Ubukata Makoto

  Division Of Applied Bioscience Graduate School Of Agriculture Hokkaido University

• Mitsuhashi Shinya

  Division Of Applied Bioscience Graduate School Of Agriculture Hokkaido University

• UBUKATA Makoto

  Division of Applied Bioscience, Research Faculty of Agriculture, Hokkaido University

• OLESEN Sanne

  Drug Discovery Department, H. Lee Moffitt Cancer Center and Research Institute

• YANG Yan

  Drug Discovery Department, H. Lee Moffitt Cancer Center and Research Institute

• SCHÖNBRUNN Ernst

  Drug Discovery Department, H. Lee Moffitt Cancer Center and Research Institute

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• Relationship between ATM and Ribosomal Protein S6 Revealed by the Chemical Inhibition of Ser/Thr Protein Phosphatase Type 1
• Cleavage of α-Dicarbonyl Comopunds by Terpene Hydroperoxide
• MurA as a Primary Target of Tulipalin B and 6-Tuliposide B
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