Nucleosome Distribution near the 3′ Ends of Genes in the Human Genome

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概要

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• By systematic analysis of high-throughput sequencing datasets from the human genome, we found that protein-coding genes have a specific chromatin structure near transcription termination sites relative to non-coding genes, one related to polyadenylation. Nucleosome was depleted near the site of cleavage/polyadenylation (polyA site) regardless of its relative position in the gene. DNA sequence plays an improtant role in nucleosome distribution, and conservative sequence elements and the protein binding to them are major determinants in causing nucleosome depletion near polyA sites. Furthermore, nucleosome occupancy was regulated by gene transcription and RNA polymerase II (RNAPII) occupancy. Our results reveal influences on nucleosome occupancy near polyadenylation sites and constitute evidence indicating that nucleosome distribution regulates 3′ end processing of protein-coding genes.

• 公益社団法人 日本農芸化学会の論文

著者

• SUN Xiao

  State Key Laboratory of Bioelectronics, Southeast University

• HUANG Huan

  State Key Laboratory of Bioelectronics, Southeast University

• LIU Hongde

  State Key Laboratory of Bioelectronics, Southeast University

関連論文

• Nucleosome Distribution near the 3′ Ends of Genes in the Human Genome

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