Design and Synthesis of Amide Derivatives as S-Adenosyl-L-Homocysteine Hydrolase Inhibitors
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概要
- 論文の詳細を見る
In this study, a series of mide derivatives were synthesized and evaluated for their S-adenosyl-L-homocysteine hydrolase (SAHase) inhibitory activities. The results demonstrated that most of compounds displayed potent SAHase inhibitory activities. Interestingly, compounds 11 and 14 exhibited more potent inhibitory effects than the aristeromycin, one of the most potent SAHase inhibitors known so far. Compounds 12, 13, 15 and 17 exhibited a moderate effect (IC50 < 10.0 μM). The structure-activity relationship found that compounds with substituted indazole-5-yl group at Ar position and ethylamino group at the side chain showed better SAHase inhibitory activities.
- 公益社団法人 日本薬学会の論文
著者
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Wang Panfeng
Shanghai Shyndec Pharmaceutical Co., Ltd
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Wang Panfeng
Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry
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Tan Xiangduan
Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry
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Nian Siyun
Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry
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Wang Guoping
Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry
関連論文
- Synthesis of Substituted 6-Amino-4-(2, 4-dimethoxyphenyl)-[1, 2] dithiolo [4, 3-b] pyrrol-5-ones and Their Raising Leukocyte Count Activities
- Design and Synthesis of Amide Derivatives as S-Adenosyl-L-Homocysteine Hydrolase Inhibitors