An Efficient Green Multi-Component Reaction Strategy for the Synthesis of Highly Functionalised Pyridines and Evaluation of Their Antibacterial Activities

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概要

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• An efficient green multi-component reaction (MCR) method has been developed for the synthesis of 2-amino-4-aryl/heteroaryl-6-(pyridin-2-ylthio)pyridine-3,5-dicarbonitrile(s) via a 3-component reaction of aryl aldehyde(s), malononitrile and 2-mercaptopyridine in the presence of K2CO3 under solvent free reaction conditions (SFRC) using grinding technique at room temperature in a single step. The advantages of the present protocol is operationally simple, environmentally benign, solvent-free reaction conditions (SFRC), simple work up, excellent isolated yields of desired products and viable method for large scale applications in pharmaceutical industry. Interestingly, the synthesized compounds showed moderate to excellent antibacterial activities against Gram-positive and Gram-negative bacterial strains.

• 公益社団法人 日本薬学会の論文

著者

• Gangi Reddy

  Department of Chemistry, School of Physical Sciences, Yogi Vemana University

• Mohan Reddy

  Department of Chemistry, School of Physical Sciences, Yogi Vemana University

• Ram Reddy

  Dr. Reddy's Laboratories Limited

• Srinivasula Reddy

  Department of Chemistry, Sri Venkateswara University

• Mahesh Avula

  Dr. Reddy's Laboratories Limited

• Lingappa Yeramanchi

  Department of Chemistry, Sri Venkateswara University

• Mahesh Avula

  Dr. Reddy's Laboratories Limited

関連論文

• An Efficient Green Multi-Component Reaction Strategy for the Synthesis of Highly Functionalised Pyridines and Evaluation of Their Antibacterial Activities

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