Control of cell differentiation by mechanical stress

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概要

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• Cells sense mechanical force and their physical environment to change their fate and behavior through mechanotransduction. The mechanotransduction is, by translating mechanical forces and deformations into biochemical intracellular signaling, changing gene expressions and adjusting cellular and extracellular structure. Given that mechanosensitive signaling modulates cellular functions as diverse as proliferation and differentiation, such signaling is crucial for normal tissue development and homeostasis. Here we review current evidence for the mechanical regulation of cell differentiation, specifically in musculoskeletal tissues, such as skeletal muscle, fat, bone, and cartilage.

著者

• Akimoto Takayuki

  Division of Biomedical Materials and Systems, Center for Disease Biology and Integrative Medicine Fa

• PARK Jong-Hoon

  Division of Regenerative Medical Engineering, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo

• Ushida Takashi

  Division of Regenerative Medical Engineering, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo

• USHIDA Takashi

  Division of Biomedical Materials and Systems, Center for Disease Biology and Integrative Medicine, School of Medicine, The University of Tokyo

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