Lenalidomide induced graft-versus-host disease in a patient with relapsed multiple myeloma three and a half years after allogeneic hematopoietic stem cell transplantation

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概要

• 論文の詳細を見る

• Lenalidomide is indicated for treatment of patients with relapsed or refractory multiple myeloma. The main toxicities related to this drug are severe neutropenia and thrombocytopenia. Lenalidomide-associated eosinophilic pneumonia with skin rash is rare. We report a patient who developed dyspnea with skin rash during lenalidomide treatment for relapsed myeloma three and a half years after allogeneic hematopoietic stem cell transplantation (allo- HSCT). Bronchoalveolar lavage (BAL) analysis revealed increased eosinophils, but no sign of infection. Skin biopsy findings showed graft-versus-host disease (GVHD). We made a diagnosis of eosinophilic pulmonary syndrome associated with GVHD. This case suggests that even three and a half years after performing allo-HSCT, lenalidomide therapy may induce GVHD. Consequently, lenalidomide therapy in such patients should be applied carefully while taking GVHD into consideration.

• The Japan Society for Hematopoietic Stem Cell Transplantationの論文

著者

• YOSHIDA HARUHIKO

  Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of To

• Minamizaki Takeshi

  Department Of Orthopaedic Surgery Tottori University

• SUZUKI YOSHIMASA

  Department of Thoracic and Cardiovascular Surgery, Tottori Prefectural Central Hospital

• Kawatani Toshio

  Stem Cell Transplantation Center, Yonago Medical Center, National Hospital Organization

• Tajima Fumihito

  Stem Cell Transplantation Center, Yonago Medical Center, National Hospital Organization

• Koda Masaharu

  Department of Industrical Chemistry, Niihama Technical College Niihama

• Kure Akira

  Stem Cell Transplantation Center, Yonago Medical Center, National Hospital Organization

• Yoshida Haruhiko

  Division of Pathology, Yonago Medical Center, National Hospital Organization

• Ueda Yasuhito

  Department of Pulmonary Medicine, Yonago Medical Center, National Hospital Organization

• Tetsuo Yamamoto

  Department of Internal Medicine, Yonago Medical Center, National Hospital Organization

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