Associations of Gallbladder Polyps with Metabolic Syndrome and Lifestyle

概要

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Objective: To determine whether gallbladder polyps (GBP) are associated with lifestyle variables and/or metabolic syndrome in healthy Japanese people. Methods: We studied 18,540 subjects (10,911 men and 7,629 women) visiting our general health examination center between 2004 and 2010 who gave written informed consent. Those with viral hepatitis or other chronic liver diseases and those who had undergone cholecystectomy were excluded. Results: GBP were found in 1,860 (10.0%) subjects. Patients in the GBP group were significantly older and had significantly higher LDL-C levels, LDL/HDL ratios, and non-HDL levels than those in the no-GBP group. As for lifestyle variables, the frequencies of habitual smoking and coffee drinking were significantly higher in men in the GBP group. The prevalence of GBP was lower in subjects who drank alcohol. Multivariate analysis revealed independent risk factors for GBP to be aging in both men and women, while smoking and coffee drinking habits were predictors only in men. Drinking alcohol was an inhibitory factor for GBP in men. The presence of metabolic syndrome was not associated with GBP in either men or women. Conclusion: GBP were found to be associated with smoking, coffee drinking, dyslipidemia, and aging, while there was no apparent association with metabolic syndrome.