Proposed System of Management for Men with Abnormal Prostate-specific antigen (PSA) Tests in Health Check-up

概要

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Background: Carcinoma of the prostate continues to be a major health problem in Japan. The incidence of prostate cancer is increasing. The degree of variability in PSA measurements is important for interpreting the results of this test in screening programs, particularly for interpreting the significance of changes in repeated tests. There is also the issue of how we should manage cases of abnormal PSA values within a health check-up.Subjects and Methods: Serum prostate-specific antigen (PSA)-based prostate cancer screening was conducted on healthy Japanese seamen between 2005 and 2007. To determine the long-term intra-individual variation in PSA in healthy men, we analyzed the annual changes in PSA levels in 164 men who underwent PSA measurement continuously for three years. Results: The levels of serum PSA in this group were relatively low, and the PSA levels in each person with a level less than 2.0ng/mL at the first measurement (baseline PSA) remained steady for 3 years.Conclusion: Individuals with a PSA level of more than 4.0 ng/mL and those in whom there is an increase in PSA level of more than 2.0 ng/mL at the second round of screening in a health check-up should be further evaluated by specialists.