Role of Triglyceride, Adiponectin, and Body Mass Index in Identifying Insulin Resistance in Japanese Isolated Impaired Glucose Tolerance Male Subjects

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概要

• 論文の詳細を見る

• <B>Background</B> Japanese subjects with impaired glucose tolerance (IGT) are unique in that they can be divided into two variants: one with insulin resistance and the other with normal insulin sensitivity. The factors responsible for insulin resistance in IGT subjects, however, are not fully clarified.<B>Methods</B> Ninety-seven Japanese isolated IGT male subjects were recruited for the assessment of insulin action (homeostasis model assessment insulin resistance (HOMA-IR)), fasting lipid profile, and other variables including high molecular weight adiponectin (HMW adiponectin). <B>Results</B> BMI and HOMA-IR were 24.1±0.3 kg/m2(range, 17.7 to 33.1) and 1.09±0.08 (range, 0.19 to 5.92), respectively. Thus, there was a wide variation in BMI and HOMA-IR in these subjects. Univariate and multivariate analyses revealed a strong, independent association between HOMA-IR and age, BMI, or HDL cholesterol in all subjects studied. In contrast, analysis of the midrange BMI group (21.5 to 27.0kg/m2) showed that HOMA-IR was independently associated with serum TG and serum HMW adiponectin but was not associated with age, BMI, or HDL cholesterol.<B>Conclusions</B> Firstly, Japanese isolated IGT male subjects had a wide range of insulin sensitivity index, indicating that they could be divided into two variants: insulin resistance and normal insulin sensitivity. Secondly, the degree of BMI per se affects the factors associated with insulin resistance in isolated IGT male subjects. Finally, Japanese isolated IGT male subjects without insulin resistance have a low cardiovascular disease risk factor whereas those with insulin resistance have a markedly increased cardiovascular disease risk factor. (Ningen Dock 2011; 25: 31-36)

• 日本人間ドック学会の論文

著者

• Yutaka Seino

  Kansai Electric Power Hospital

• Shoichiro Nagasaka

  Division of Endocrinology and Metabolism, Jichi Medical University

• Yoshikatsu Nakai

  Karasuma-Oike Nakai Clinic

• Mitsuo Fukushima

  Division of Clinical Nutrition and Internal Medicine, Okayama Prefectural University

• Ataru Taniguchi

  Division of Diabetes and Endocrinology, Kyoto Preventive Medical Center

• Fusanori Nishimura

  Department of Dental Science for Health Promotion, Hiroshima University Graduate School of Biomedical Sciences

• Takahide Okumura

  Department of Pharmacy, Saiseikai-Nakatsu Hospital

• Naoya Watanabe

  Health Care and Promotion Center, Yodogawa Christian Hospital

関連論文

• Role of Triglyceride, Adiponectin, and Body Mass Index in Identifying Insulin Resistance in Japanese Isolated Impaired Glucose Tolerance Male Subjects

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