卵巣未熟奇形腫術後化学療法中に生じたgrowing teratoma syndromeを腹腔鏡下手術で診断し得た一例

概要

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A 37-year-old woman developed growing teratoma syndrome (GTS) involving an immature teratoma of the ovary that developed during adjuvant platinum-based chemotherapy. At initial surgery, the patient was diagnosed with immature teratoma of the ovary (pT2c (a) NxM0) with peritoneal and contralateral disseminations. After the fertility-sparing surgery, she underwent chemotherapy with BEP comprising bleomycin, etoposide, and platinum. During adjuvant chemotherapy, her serum alpha-fetoprotein level normalized; however, the size of the pelvic tumor increased. She underwent laparoscopic surgery for her peritoneal dissemination. Surgical specimen indicated a mature teratoma. No recurrence was observed after the second operation. The possibility of GTS should be considered in the follow-up of a patient with previous history of an ovarian germ cell tumor. GTS is defined as an enlargement of a mature teratoma, which arises during or after chemotherapy for malignant germ cell tumors. When GTS is suspected, surgery should be considered. In our case, GTS was successfully treated using laparoscopic surgery.