口腔乾燥症に対する保湿スプレーの使用感調査

概要

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We examined the effect of a moisturizing mouth spray which contains lactoferrin, β-glucan, and hyaluronic acid as active ingredients, on 13 outpatients with xerostomia sensation and two inpatients with serious xerostomia.The spray was used for these outpatients for 2 weeks, and the subjective symptoms regarding oral conditions before and after usage were evaluated by a questionnaire, consisting of 14 questions, using the five-point categorical Likert scale. According to the comparison between before and after the spray usage in each of the 14 questions by the Wilcoxon-signed rank test, oral dryness was significantly improved and mucous membrane pain was significantly reduced.For the two patients with serious xerostomia, the moisture content of oral mucosa was measured by a moisture checker. The values of the moisture checker after spraying were 4.6- and 12.6-fold higher at 5 min than those before spraying, and were at least maintained (7.1-fold and 13.0-fold, respectively) at 10 min. After three weeks of using the spray, the values were 18.6- and 20.4-fold greater than the initial levels.These results suggest that the spray containing lactoferrin, β-glucan, and hyaluronic acid effectively improved xerostomia both subjectively and objectively.