Efficacy of pregabalin therapy for patients with oral cancer in terminal stage

概要

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We have often experienced the uncontrollable situation for cancer pain, especially peripheral pain such as numb, burning, and tingling even if using NSAIDs and/or opioids. It is recommended for such neuropathic pain to use some adjuvant analgesics. Pregabalin was approved for treatment of peripheral neuropathic pain besides postherpetic neuralgia and diabetic peripheral neuropathy in 2010. We started to use the medicine for oral cancer patients accompanied with peripheral neuropathic pain. In this study we investigated the efficacy of pregabalin as additional therapy on each characteristics of cancer pain. We have experienced 6 cases with oral cancer in terminal stage using the medicine. In almost all cases, pain was reduced at the end of the observation period. We were able to gain a good management of peripheral pain treated with pregabalin.