精神科との連携にて，統合失調症を合併したC型慢性肝炎に対するIFN療法を行いウイルス学的著効が得られた3症例

概要

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IFN therapy for chronic hepatitis C is associated with significant neuropsychiatric side effects. In Japan, the patients with shizophrenia are less likely to receive IFN therapy, despite limited data regarding the influence of IFN therapy on their psychiatric symptoms. We present three patients with shizophrenia who had the treatment with IFN for chronic hepatitis C in cooperation with psychiatrists. They were able to tolerate IFN therapy, resulting in sustained viral response (SVR). The key components which enabled them to complete the coarse of treatment are the following: 1) initial stabilization of psychiatric symptoms prior to treatment; 2) close collaboration between the patient, the psychiatric team and the internal medicine team; and 3) close observation for changes in mental status with several psychiatric scoring systems.